Journal: Quantitative Imaging in Medicine and Surgery
Article Title: Heterogeneity of fibroblast activation protein expression in the microenvironment of an intracranial tumor cohort: head-to-head comparison of gallium-68 FAP inhibitor-04 ( 68 Ga-FAPi-04) and fluoride-18 fluoroethyl-L-tyrosine ( 18 F-FET) in positron emission tomography-computed tomography imaging
doi: 10.21037/qims-24-82
Figure Lengend Snippet: Typical case illustrations of FAP immunohistochemical staining imaging (original magnification, 200×). (A) WHO grade 4 glioblastoma IDH-wt (No. 1) with moderate FAP expression in tumor stroma and perivascular region. (B) Metastatic carcinoma (No. 15) with significant FAP expression in tumor stroma, perivascular region, and small-vessel epithelial tissue. (C) Medulloblastoma (No. 21) with mild FAP expression in the tumor stroma. (D) Multifocal encephalomalacia (No. 13) with moderate FAP expression in stromal cells in inflamed regions, perivascular region, small-vessel epithelial tissue, and gliotic region. FAP, fibroblast activation protein; WHO, World Health Organization; IDH, isocitrate dehydrogenase; wt, wild type.
Article Snippet: Characteristic surgical resection slices were selected for FAP immunohistochemistry staining as per the FAP kit instruction (Abcam, Cambridge, UK).
Techniques: Immunohistochemical staining, Staining, Imaging, Expressing, Activation Assay